PUBLICATIONS (Google Scholar Profile):
2024
C.C. Cole, D.R. Walker, S.A.H. Hulgan, B.H. Pogostin, J.W.R. Swain, M.D. Miller, W. Xu, R. Duella, M. Misiura, X. Wang, A.B. Kolomeisky, G.N. Phillips Jr., and J.D. Hartgerink "Heterotrimeric Collagen Helix with High Specificity of Assembly Results in a Rapid Rate of Folding" accepted for publication in Nature Chemistry.
V. Leyva-Aranda, S. Singh, M. Telesforo, S. Young, C. Yee, J. D. Hartgerink, "Nanofibrous MultiDomain Peptide hydrogels provide T cells a 3D, cytocompatible environment for cell expansion and antigen specific killing" ACS Biomaterials Science & Engineering 2024, available online. DOI: 10.1021/acsbiomaterials.3c01617
2023
C. Cole, L. T. Yu, M. Misiura, J. Williams III, T. Bui, J. D. Hartgerink "Stabilization of Synthetic Collagen Triple Helices: Charge Pairs and Covalent Capture" Biomacromolecules 2023, 24, 11, 5083–5090. DOI: 10.1021/acs.biomac.3c00680
J. W. R. Swain, C. Y. Yang, and J. D. Hartgerink "Orthogonal Self-Assembly of Amphiphilic Peptide Hydrogels and Liposomes Results in Composite Materials with Tunable Release Profiles" Biomacromolecules 2023, 24, 11, 5018–5026. DOI: 10.1021/acs.biomac.3c00664
A. Hernandez, J. D. Hartgerink, S. Young "Self-assembling peptides as immunomodulatory biomaterials" Front. Bioeng. Biotechnol. 2023, 11:1139782. DOI: 10.3389/fbioe.2023.1139782
L. T. Yu, M. C. Hancu, M. A. B. Kreutzberger, A. Henrickson, B. Demeler, E. H. Egelman, J. D. Hartgerink "Hollow Octadecameric Self-Assembly of Collagen-like Peptides" J. Am. Chem. Soc. 2023 145, 9, 5285–5296. DOI: 10.1021/jacs.2c12931
A. C. Farsheed, A. J. Thomas, B. H. Pogostin, J. D. Hartgerink "3D Printing of Self-assembling Nanofibrous Multidomain Peptide Hydrogels" Adv. Mater. 2023, 2210378. DOI: 10.1002/adma.202210378
B. H. Pogostin, G. Saenz, C. Cole, E. Euliano, J. D. Hartgerink, K. McHugh "Dynamic Imine Bonding Facilitates Mannan Release from a Nanofibrous Peptide Hydrogel" Bioconjugate Chem. 2023, 34, 1, 193–203 DOI: 10.1021/acs.bioconjchem.2c00461
H. A. Pearce, J. W. R. Swain, L. H. Victor, K. J. Hogan, E. Y. Jiang, M. L. Bedell, A. M. Navara, A. Farsheed, Y. S. Kim, J. L. Guo, J. D. Hartgerink, K. J. Grande-Allen, A. G. Mikos "Thermogelling hydrogel charge and lower critical solution temperature influence cellular infiltration and tissue integration in an ex vivo cartilage explant model" J. Biomed. Mater. Res. 2023, 1, 15-34. DOI: 10.1002/jbm.a.37441
2022
C. C. Cole, M. Misiura, S. A. H. Hulgan, C. M. Peterson, J. W. Williams III, A. B. Kolomeisky, J. D. Hartgerink "Cation-π Interactions and their Role in Assembling Collagen Triple Helices" Biomacromolecules 2022, 23, 11 4645-4654. DOI: 10.1021/acs.biomac.2c00856
B. H. Pogostin, M. H. Yu, A. R. Azares, E. M. Euliano, C. S. E. Lai, G. Saenz, S. X. Wu, A. C. Farsheed, S. M. Melhorn, T. P. Graf, D. G. Woodside, J. D. Hartgerink, K. J. McHugh "Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity" Biomater. Sci. 2022, 10, 6217-6229. DOI: 10.1039/D2BM01242A
C. S. E. Lai, V. Leyva-Aranda, V. H. Kong, T. L. Lopez-Silva, A. C. Farsheed, C. D. Cristobal, J. W. R. Swain, H. K. Lee, J. D. Hartgerink "A Combined Conduit-Bioactive Hydrogel Approach for Regeneration of Transected Sciatic Nerves" ACS Applied Bio Materials 2022, 5, 10, 4611-4624. DOI: 10.1021/acsabm.2c00132
J. C. Chen, P. Kan, Z. Yu, F. Alrashdan, R. Garcia, A. Singer, C. S. E. Lai, B. Avants, S. Crosby, Z. Li, B. Wang, M. M. Felicella, A. Robledo, A. V. Peterchev, S. M. Goetz, J. D. Hartgerink, S. A. Sheth, K. Yang, J. T. Robinson "A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves" Nature Biomedical Engineering 2022, 6, 706–716. DOI: 10.1038/s41551-022-00873-7
C. M. Peterson, M. R. Helterbrand, J. D. Hartgerink "Covalent Capture of a Collagen Mimetic Peptide with an Integrin Binding Motif" Biomacromolecules 2022, 23, 6, 2396-2403. DOI: 10.1021/acs.biomac.2c00155
S. A. H. Hulgan, J. D. Hartgerink "Recent Advances in Collagen Mimetic Peptide Structure and Design" Biomacromolecules 2022, 23, 4, 1475-1489. DOI: 10.1021/acs.biomac.2c00028.
L. T. Yu, J. D. Hartgerink "Selective Covalent Capture of Collagen Triple Helices with a Minimal Protecting Group Strategy" Chemical Science 2022, 13, 2789-2796. DOI: 10.1039/D1SC06361H
2021
H. A Pearce, E. Y. Jiang, J. W. R. Swain, A. M. Navara, J. L. Guo, Y. S. Kim, A. Woehr, J. D. Hartgerink, A. G. Mikos "Evaluating the physicochemical effects of conjugating peptides into thermogelling hydrogels for regenerative biomaterials applications" Regenerative Biomaterials 2021, 8, 6, rbab073. DOI: 10.1093/rb/rbab073.
D. R. Walker, A. A. Alizadehmojarad, A. Kolomeisky, J. D. Hartgerink "Charge-free, stabilizing amide-π interactions can be used to control collagen triple helix self-assembly" Biomacromolecules 2021 22, 5, 2137-2147. DOI: 10.1021/acs.biomac.1c00234.
D. R. Walker, S. A. Hulgan, C. M. Peterson, I. Li, K. J. Gonzalez, J. D. Hartgerink "Predicting the stability of homotrimeric and heterotrimeric collagen helices" Nature Chem. 2021 13, 260-269. DOI: 10.1038/s41557-020-00626-6.
Y. Shi, T. Xie, D. G Leach, B. Wang, S. Young, A. A. Osman, A. G. Sikora, X. Ren, J. D. Hartgerink, J. N. Myers, R. Rangel “Local anti-PD-1 delivery prevents progression of premalignant lesions in a 4NQO-oral carcinogenesis mouse model” Cancer Prevention Res. 2021, 14, 8, 767-777. DOI: 10.1158/1940-6207.CAPR-20-0607.
D. G. Leach, N. Dharmaraj, T. L. Lopez-Silva, J. R. Venzor, B. H. Pogostin, A. G. Sikora, J. D. Hartgerink, S. Young "Biomaterial-Facilitated Immunotherapy for Established Oral Cancers" ACS Biomaterials Sci. Eng. 2021, 7, 2, 415-421. DOI: 10.1021/acsbiomaterials.0c01575.
N. M. Muñoz, M. Williams, K. Dixon, C. Dupuis, A. McWatters, R. Avritscher, S. Z. Manrique, K. McHugh, R. Murthy, A. Tam, A. Naing, S. P. Patel , D. Leach, J. D. Hartgerink, S. Young, P. Prakash, P. Hwu, R. A. Sheth "Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy" J. ImmunoTherapy Cancer 2021, 9, e001800. DOI: 10.1136/jitc-2020-001800.
Y. Shi, T. Xie, D. G. Leach, B. Wang, S. Young, A. A. Osman, A. G. Sikora, X. Ren, J. D. Hartgerink, J. N. Myers, R. Rangel "Local anti-PD-1 delivery prevents progression of premalignant lesions in a 4NQO-oral carcinogenesis mouse model" Cancer Prev. Res. 2021, 14, 767-768. DOI: 10.1158/1940-6207.CAPR-20-0607.
T. L. Lopez-Silva, C. D. Cristobal, C. S. E. Lai, V. Leyva-Aranda, H. K. Lee, J. D. Hartgerink "Self-assembling Multidomain Peptide Hydrogels accelerate Peripheral Nerve Regeneration after Crush Injury" Biomaterials 2021, 265, 120401. DOI: 10.1016/j.biomaterials.2020.120401. (This publication was made available online in its final form in September 2020 but was organized for the January 2021 issue of Biomaterials.)
2020
S. A. H. Hulgan, A. A. Jalan, I. Li, D. R. Walker, M. D. Miller, A. J. Kosgei, W. Xu, G. N. Phillips, J. D. Hartgerink "Covalent Capture of Collagen Triple Helices using Lysine-Aspartate and Lysine-Glutamate Pairs" Biomacromolecules 2020, 21, 3772−3781. DOI: 10.1021/acs.biomac.0c00878.
A. A. Jalan, D. Sammon, J. D. Hartgerink, P. Brear, K. Stott, S. W. Hamaia, E. J. Hunter, D. R. Walker, B. Leitinger and R. W. Farndale “Chain alignment of collagen I deciphered using computationally designed heterotrimers” Nature Chem. Biol. 2020, 16, 423-429. DOI: 10.1038/s41589-019-0435-y.
T. L. Lopez-Silva, D. G. Leach, A. Azares, I. Li, D. G. Woodside, J. D. Hartgerink “Chemical functionality of multidomain peptide hydrogels governs early host T immune response” Biomaterials 2020, 231, 119667. DOI: 10.1016/j.biomaterials.2019.119667.
2019
D. G. Leach, J. M. Newton, M. A. Florez, T. L. Lopez-Silva, A. A. Jones, S. Young, A. G. Sikora, and J. D. Hartgerink “Drug-Mimicking Nanofibrous Peptide Hydrogel for Inhibition of Inducible Nitric Oxide Synthase” ACS Biomater. Sci. Eng. 2019, 5, 6755-6765. DOI: 10.1021/acsbiomaterials.9b01447.
I. Li, S. A. H. Hulgan, D. R. Walker, R. W. Farndale, J. D. Hartgerink, and A. A. Jalan “Covalent Capture of a Heterotrimeric Collagen Helix” Org. Lett. 2019, 21, 5480-5484. DOI: 10.1021/acs.orglett.9b01771.
D. G. Leach, S. Young, J. D. Hartgerink “Advances in immunotherapy delivery from implantable and injectable biomaterials” Acta Biomaterialia 2019, 88, 15-31. DOI: 10.1016/j.actbio.2019.02.016.
T. L. Lopez-Silva, D. G. Leach, I. Li, X. Wang, J. D. Hartgerink “Self-Assembling Multidomain Peptides: Design and Characterization of Neutral Peptide-Based Materials with pH and Ionic Strength Independent Self-Assembly” ACS Biomaterials Sci. Eng. 2019, 5, 977-985. DOI: 10.1021/acsbiomaterials.8b01348.
2018
N. C. Carrejo, A. N. Moore, T. L. Lopez Silva, D. G. Leach, I. Li, D. R. Walker, J. D. Hartgerink “Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice” ACS Biomaterials Sci. Eng. 2018, 4, 1386-1396. DOI: 10.1021/acsbiomaterials.8b00031.
D. G. Leach, N. Dharmaraj, S. L. Piotrowski, T. L. Lopez-Silva, Y. Lei, A. G. Sikora, S. Young and J. D. Hartgerink “STINGel: Controlled Release of a Cyclic Dinucleotide for Enhanced Cancer Immunotherapy” Biomaterials 2018, 163, 67-75. DOI: 10.1016/j.biomaterials.2018.01.035.
A. N. Moore, T. L. Lopez Silva, N. C. Carrejo, C. A. Marmolejo Origel, I. Li and J. D. Hartgerink “Nanofibrous Peptide Hydrogel Elicits Angiogenesis and Neurogenesis without Drugs, Proteins, or Cells” Biomaterials 2018, 161, 154-163. DOI: 10.1016/j.biomaterials.2018.01.033.
2017
I. Li and J. D. Hartgerink “Covalent Capture of Aligned Self-Assembling Nanofibers” J. Am. Chem. Soc., 2017, 139, 8044–8050. DOI: 10.1021/jacs.7b04655.
A. M. Acevedo-Jake, D. H. Ngo and J. D. Hartgerink “Control of Collagen Triple Helix Stability by Phosphorylation” Biomacromolecules 2017, 18, 1157-1161. DOI: 10.1021/acs.biomac.6b01814.
A. N. Moore and J. D. Hartgerink “Self-Assembling Multidomain Peptide Nanofibers for Delivery of Bioactive Molecules and Tissue Regeneration” Acc. Chem. Res. 2017, 50, 714-722. DOI: 10.1021/acs.accounts.6b00553.
K. A. Clements, A. M. Acevedo-Jake, D. R. Walker and J. D. Hartgerink “Glycine Substitutions in Collagen Heterotrimers Alter Triple Helical Assembly” Biomacromolecules 2017, 18, 617-624. DOI: 10.1021/acs.biomac.6b01808.
2016
I. Li, A. N. Moore and J. D. Hartgerink, “Missing Tooth Multidomain Peptide Nanofibers for Delivery of Small Molecule Drugs” Biomacromolecules 2016, 17 (6) 2087 - 2095. DOI: 10.1021/acs.biomac.6b00309.
V. A. Kumar , Q. Liu , N. C Wickremasinghe , S. Shi , T. T. Cornwright , Y. Deng, A. Azares, A. N Moore, A. M. Acevedo-Jake, N. Agudo, S. Pan, D. G. Woodside, P. Vanderslice, J. T. Willerson, R. A. Dixon, J. D. Hartgerink “Treatment of hind limb ischemia using angiogenic peptide nanofibers” Biomaterials 2016, 98, 113-119. DOI: 10.1016/j.biomaterials.2016.04.032.
A. M. Acevedo-Jake, K. A. Clements, and Jeffrey D. Hartgerink “Synthetic, Register-Specific, AAB Heterotrimers to Investigate Single Point Glycine Mutations in Osteogenesis Imperfecta” Biomacromolecules 2016, 17, 914-921. DOI: 10.1021/acs.biomac.5b01562.
2015
V. A. Kumar, N. C. Wickremasinghe, S. Shi, and J. D. Hartgerink “Nanofibrous Snake Venom Hemostat” ACS Biomaterials Sci. Eng. 2015, 1, 1300-1305. DOI: 10.1021/acsbiomaterials.5b00356.
N. C. Wickremasinghe, V. A. Kumar, S. Shi, and J. D. Hartgerink "Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels" ACS Biomaterials Sci. Eng. 2015, 1, 845-854. DOI: 10.1021/acsbiomaterials.5b00210.
A. Moore, S. C. Perez, J. D. Hartgerink, R. N. D'Souza, and J. Colombo "Ex Vivo Modeling of Multidomain Peptide Hydrogels with Intact Dental Pulp" J. Dental Res. 2015, 94, 12, 1773-1781. DOI: 10.1177/0022034515600380.
V. A. Kumar, N. L. Taylor, S. Shi, N. C. Wickremasinghe, R. N. D'Souza and J. D. Hartgerink "Self-assembling multidomain peptides tailor biological responses through biphasic release" Biomaterials 2015, 52, 71-78. DOI: 10.1016/j.biomaterials.2015.01.079.
V. A. Kumar, S. Shi, B. K. Wang, I. Li, A. A. Jalan, B. Sarkar, N. C. Wickremasinghe and J. D. Hartgerink, "Drug-Triggered and Cross-Linked Self-Assembling Nanofibrous Hydrogels" J. Am. Chem. Soc. 2015, 137 4823-4830. DOI: 10.1021/jacs.5b01549.
V. A. Kumar, N. L. Taylor, S. Shi, B. K. Wang, A. A. Jalan, M. K. Kang, N. C. Wickremasinghe, J. D. Hartgerink “Highly Angiogenic Peptide Nanofibers” ACS Nano, 2015, 9, 860-868. DOI: 10.1021/nn506544b.
A. M. Acevedo-Jake, A. A. Jalan, J. D. Hartgerink “Comparative NMR Analysis of Collagen Triple Helix Organization from N- to C-Termini” Biomacromolecules, 2015, 16, 145-155. DOI: 10.1021/bm501281a.
2014
B. Sarkar, L. E. R. O’Leary, J. D. Hartgerink “Self-Assembly of Fiber-Forming Collagen Mimetic Peptides Controlled by Triple-Helical Nucleation” J. Am. Chem. Soc., 2014, 136, 14417-14424. DOI: 10.1021/ja504377s.
N. C. Wickremasinghe, V. A. Kumar, J. D. Hartgerink “Two-Step Self-Assembly of Liposome-Multidomain Peptide Nanofiber Hydrogel for Time-Controlled Release” Biomacromolecules, 2014 15, 3587-3595. DOI: 10.1021/bm500856c.
J. S. Colombo, A. N. Moore, J. D. Hartgerink, R. N. D’Souza “Scaffolds to Control Inflammation and Facilitate Dental Pulp Regeneration” J. Endodontics, 2014, 40, S6-S12. DOI: 10.1016/j.joen.2014.01.019.
A. A. Jalan, K. A. Jochim, J. D. Hartgerink “Rational Design of a Non-canonical “Sticky-ended” ABC-Collagen Triple Helix” J. Am. Chem. Soc., 2014, 136, 7535-7538. DOI: 10.1021/ja5001246.
M. K. Kang, J. Colombo, R.N. D'Souza, J. D. Hartgerink “Sequence effects of self-assembling MultiDomain Peptide Hydrogels on encapsulated SHED cells” Biomacromolecules, 2014, 15, 2004-2011. DOI: 10.1021/bm500075r.
V. A. Kumar, N. L. Taylor, A. A. Jalan, L. K. Hwang, B. K. Wang, Jeffery D. Hartgerink “A Novel Synthetic Collagen Mimic for Hemostasis” Biomacromolecules 2014, 15, 1484−1490. DOI: 10.1021/bm500091e.
2013
A. A. Jalan, J. D. Hartgerink “Pairwise interactions in collagen and the design of heterotrimeric helices” Curr. Opin. Chem. Biol. 2013, 17, 6, 960–967. DOI: 10.1016/j.cbpa.2013.10.019.
A. A. Jalan, B. Demeler, J. D. Hartgerink “Hydroxyproline-Free Single Composition ABC Collagen Heterotrimer” J. Am. Chem. Soc. 2013, 135, 6014-6017. DOI: 10.1021/ja402187t.
E. L. Bakota, O. Sensoy, B. Ozgur, M. Sayar, and J. D. Hartgerink “Self-Assembling Multidomain Peptide Fibers with Aromatic Cores” Biomacromolecules 2013, 14, 1370–1378. DOI:10.1021/bm4000019.
A. A. Jalan and J. D. Hartgerink “Simultaneous Control of Composition and Register of an AAB-type Collagen Heterotrimer” Biomacromolecules 2013, 14, 179-185. DOI:10.1021/bm3015818.
2012
J. A. Fallas and J. D. Hartgerink “Computational Design of Self-Assembling Register-Specific Collagen Heterotrimers” Nat. Comm. 2012, 3, 1087. DOI:10.1038/ncomms2084.
F. Wei, J. Fallas and J. D. Hartgerink “Sequence Position and Side Chain Length Dependence of Charge Pair Interactions in Collagen Triple Helices” Macromol. Rapid. Comm. 2012, 33 (17) 1445-1452. DOI:10.1002/marc.201200221.
J. A. Fallas, J. Dong, Y. J. Tao and J. D. Hartgerink "Structural insights into charge pair interactions in triple helical collagen-like proteins" J. Biol. Chem. 2012, 287 (11) 8039-47. DOI: 10.1074/jbc.M111.296574.
J. A. Fallas, M. A. Lee, Abhishek A. Jalan, and J. D. Hartgerink "Rational Design of Single-Composition ABC Collagen Heterotrimers" J. Am. Chem. Soc. 2012, 134, 1430-1433. DOI: 10.1021/ja209669u.
K. M. Galler, Jeffrey D. Hartgerink, A. C. Cavender, G. Schmalz and R. N. D'Souza "A Customized Self-Assembling Peptide Hydrogel for Dental Pulp Tissue Engineering" Tissue Eng. A 2012, 13 (1-2) 176-184. DOI: 10.1089/ten.TEA.2011.0222.
2011
K. M. Galler, R. N. D'Souza, M. Federlin, A. C. Cavender, J. D. Hartgerink, S. Hecker, G. Schmalz “Dentin Conditioning Codetermines Cell Fate in Regenerative Endodontics” J. Endo. 2011, 37, 11, 1536-1541. DOI: 10.1016/j.joen.2011.08.027.
L. E. R. O’Leary, J. A. Fallas, E. L. Bakota, M. K. Kang and J. D. Hartgerink "Multi-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofiber and hydrogel" Nature Chem. 2011, 3, 821-828. DOI:10.1038/nchem.1123.
W. C. Pomerantz, V. M. Yuwono, R. Drake, J. D. Hartgerink, N. L. Abbott and S. H. Gellman "Lyotropic Liquid Crystals Formed from ACHC-Rich β-Peptides" J. Am. Chem. Soc. 2011, 133 (34) 13604-13613. DOI: 10.1021/ja204874h.
K.M. Galler, R.N. D'Souza, J.D. Hartgerink, and G Schmalz "Scaffolds for Dental Pulp Tissue Engineering" Adv. Dent. Res. 2011, 23 333-339. DOI: 10.1177/0022034511405326.
E. L. Bakota, Y. Wang, F. R. Danesh, and J. D. Hartgerink "Injectable Multidomain Peptide Nanofiber Hydrogel as a Delivery Agent for Stem Cell Secretome" Biomacromolecules 2011, 12 1651-1657. DOI: 10.1021/bm200035r.
L. E. R O'Leary, J. A. Fallas and J. D. Hartgerink "Positive and Negative Design Leads to Compositional Control in AAB Collagen Heterotrimers" J. Am. Chem. Soc. 2011, 133, 5432-5443. DOI: 10.1021/ja111239r.
Y. Wang, E. Bakota, B. H. J. Chang, M. Entman, J. D. Hartgerink, and F. R. Danesh "Peptide Nanofibers Preconditioned with Stem Cell Secretome Are Renoprotective" J. Am. Soc. Nephrology. 2011, 22, 704-717. DOI: 10.1681/ASN.2010040403.
E. L. Bakota, L. Aulisa, K. M. Galler and J. D. Hartgerink "Enzymatic Cross-Linking of a Nanofibrous Peptide Hydrogel" Biomacromolecules 2011, 12, 82-87. DOI: 10.1021/bm1010195.
Before 2011
Many more (older) publications from the Hartgerink Group exist. A more complete list can be found here:
Google Scholar Profile